BET inhibitors in combination with γ-secretase inhibitors for T cell acute lymphoblastic leukemia and BRAF-inhibitor (vemurafenib) for BRAF-inhibitor...

CPI-0610 is a drug which acts as a BET inhibitor, mainly acting at the BRD2 and BRD4 subtypes. It has potential applications in the treatment of various...

stage. Small molecule inhibitors of non-BET bromodomain proteins BRD7 and BRD9 have also been developed. Chromodomain BET inhibitor BRD2 BRD3 BRD4 BRD7...

R. Herrman, B. Merkely, M. Borgman, S.E. Nissen. Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of...

inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally...

in clinical trials. Overall, there is a mean survival of 6–9 months. BET inhibitor RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: NUT midline carcinoma"...

morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally...

able to prevent successful interaction between BET proteins and acetylated histones. Using a BET inhibitor can reduce the over expression of bromodomain...

(MUFJ) keiretsu. Mitsubishi-Tanabe Pharmaceuticals developed the first BET inhibitor molecules. In August 2014, the company announced three-year research...

small-molecule inhibitor 9-ME-1. This bumped inhibitor was found to have an IC50 of 200nM and over 100-fold specificity for the L/V BET mutant BD over...