is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and...
24 KB (2,696 words) - 04:11, 13 August 2024
A CYP17A1 inhibitor is a type of drug which inhibits the enzyme CYP17A1. It may inhibit both of the functions of the enzyme, 17α-hydroxylase and 17,20-lyase...
4 KB (351 words) - 13:33, 24 January 2024
Abiraterone acetate (category CYP17A1 inhibitors)
by suppressing the production of androgens – specifically it inhibits CYP17A1 – and thereby decreases the production of testosterone. In doing so, it...
49 KB (4,213 words) - 01:54, 2 September 2024
17α-hydroxylase (CYP17A1). Using this pathway, termed Δ5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) via 17,20-lyase (CYP17A1). DHEA is...
21 KB (2,059 words) - 07:45, 3 June 2024
List of antiandrogens (section CYP17A1 inhibitors)
receptor (AR), androgen synthesis inhibitors like 5α-reductase inhibitors and CYP17A1 inhibitors, and antigonadotropins like GnRH analogues, estrogens, and progestogens...
5 KB (254 words) - 18:23, 18 September 2023
due to variants in CYP17A1, cytochrome b5, and POR may also disrupt the backdoor pathway to DHT, as the 17,20-lyase activity of CYP17A1 is required for both...
79 KB (8,729 words) - 10:41, 27 September 2024
congenital adrenal hyperplasia (CAH) resulting from a mutation in the gene CYP17A1, which produces the enzyme 17α-hydroxylase. It causes decreased synthesis...
16 KB (1,830 words) - 22:53, 22 April 2024
pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield...
149 KB (15,717 words) - 14:45, 15 September 2024
Seviteronel (category CYP17A1 inhibitors)
the treatment of prostate cancer and breast cancer. It is a nonsteroidal CYP17A1 inhibitor and works by inhibiting the production of androgens and estrogens...
11 KB (882 words) - 12:00, 13 July 2024
deficiency is a rare disorder caused by genetic mutations in the gene CYP17A1, while not affecting 17α-hydroxylase. Isolated 17,20 lyase deficiency is...
11 KB (984 words) - 04:13, 10 March 2024