Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling...
11 KB (1,388 words) - 00:36, 3 January 2024
Apoptotic caspases are subcategorised as: Initiator Caspases (Caspase 2, Caspase 8, Caspase 9, Caspase 10) Executioner Caspases (Caspase 3, Caspase 6 and...
28 KB (3,113 words) - 05:35, 29 April 2024
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
35 KB (3,948 words) - 06:00, 10 June 2024
The non-canonical inflammasomes are assembled by caspase-11 (caspases−4 and -5 in humans). Caspases-11, -4 or -5 can then cleave GSDMD to induce pyroptosis...
71 KB (7,823 words) - 11:34, 29 July 2024
called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and...
2 KB (168 words) - 22:42, 24 June 2024
Inflammasome-dependent pyroptosis involves inflammatory caspases, including caspase-1 and caspase-11 in mice, and caspases-1, -4, and -5 in humans, and is executed by...
41 KB (3,997 words) - 20:05, 13 August 2024
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
29 KB (3,392 words) - 19:09, 24 June 2024
Apoptosis (redirect from Caspase-mediated cell death)
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
91 KB (10,659 words) - 02:42, 7 July 2024
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues...
35 KB (4,330 words) - 02:13, 24 June 2024
Vishva Dixit (section Caspases and apoptosis)
mice lacking the gene that encodes caspase-1 also carry a mutation in a neighboring caspase gene, caspase-11 (caspase-4 in humans), which is responsible...
33 KB (3,467 words) - 22:38, 13 May 2024