Cyclin-dependent kinase 1 (redirect from CDK1)
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine...
25 KB (2,896 words) - 12:38, 29 August 2024
inhibitory phosphates on CDK1 and thus convert the cyclin B1-CDK1 complex to its fully activated form, MPF. Active cyclinB1-CDK1 phosphorylates and modulates...
22 KB (2,818 words) - 07:39, 3 June 2024
via cyclin B-Cdk1 phosphorylation. As these previous checkpoints are assessed, G2 protein accumulation serves to activate cyclin B-Cdk1 activity via multiple...
34 KB (4,581 words) - 11:50, 4 April 2024
at the time of discovery. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage...
14 KB (1,616 words) - 05:33, 8 February 2024
and S phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive...
6 KB (873 words) - 07:41, 3 June 2024
29 cyclins illustrates their complex regulatory roles. Key CDKs such as CDK1 are indispensable for cell cycle control, while others like CDK2 and CDK3...
35 KB (3,829 words) - 14:24, 17 June 2024
Clb6 bind and activate Cdk1, and high levels of these cyclins are required for entering S-phase. S-phase cyclin binding to Cdk1 directly stimulates DNA...
8 KB (1,120 words) - 03:33, 27 July 2016
family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle...
11 KB (1,334 words) - 11:01, 13 August 2023
Ultrasensitivity plays a large role in cell-cycle regulation. For example, Cdk1 and Wee1 are mitotic regulators, and they are able to inactivate each other...
50 KB (6,678 words) - 21:54, 13 July 2024
locations. Cyclins, when bound with the dependent kinases, such as the p34/cdc2/cdk1 protein, form the maturation-promoting factor. MPFs activate other proteins...
19 KB (1,760 words) - 11:01, 23 August 2024