The cellular apoptosis susceptibility protein (CAS) is an exportin which in the nucleus is bound to RanGTP. The Cas family of proteins are a family of...

Importin-β and displaces it from the complex. Then the cellular apoptosis susceptibility protein (CAS), an exportin which in the nucleus is bound to RanGTP...

Apoptosis (from Ancient Greek: ἀπόπτωσις, romanized: apóptōsis, lit. 'falling off') is a form of programmed cell death that occurs in multicellular organisms...

will be forced to undergo apoptosis. If the DNA damage cannot be repaired, activated p53 can induce cell death by apoptosis. It can do so by activating...

known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often...

combinations of the domains in the proteins determine its role in the apoptosis process. Members of the family that inhibit apoptosis include Bcl-2 itself, Bcl-XL...

that when one allele is mutated causes increased carcinogen susceptibility. The proteins encoded by most tumor suppressor genes inhibit cell proliferation...

known to interact with more than 300 proteins, some of which are listed below: Abl gene Androgen receptor Apoptosis-antagonizing transcription factor ARID4A...

defect in a cluster of proteins responsible for DNA repair via homologous recombination. The well-known cancer susceptibility genes BRCA1 and BRCA2 are...

targeting of proteins to intracellular degradation. In particular, parkin recognises proteins on the outer membrane of mitochondria upon cellular insult and...