Druglikeness is a qualitative concept used in drug design for how "druglike" a substance is with respect to factors like bioavailability. It is estimated...

five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or...

Furthermore, newly invented pharmacologically active moieties may have poor druglikeness and may require chemical modification to become drug-like enough to be...

and hepatic enzymes. In drug design, drug candidates may have good druglikeness but fail on first-pass metabolism because it is biochemically selective...

and logistic advantages for physicians and the military. Pharmacology Druglikeness Lipinski's rule of five Metabolite Chemogenomics Neurotransmitter Peptidomimetic...

chemists in pre-clinical drug discovery, for example, in the assessment of druglikeness of drug candidates. Likewise, it is used to calculate lipophilic efficiency...

S2CID 201716327. Gregory, Barber. "A Molecule Designed By AI Exhibits 'Druglike' Qualities". Wired. Archived from the original on 2020-04-30. Retrieved...

compounds, linking potency and lipophilicity in an attempt to estimate druglikeness. For a given compound LiPE is defined as the pIC50 (or pEC50) of interest...

Following his release from prison, in 2022, a planned software platform named Druglike controlled by Shkreli was announced with a stated aim of supporting the...

"First-Principles Calculation of the Intrinsic Aqueous Solubility of Crystalline Druglike Molecules". Journal of Chemical Theory and Computation. 8 (9): 3322–3337...