GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir...

other biological processes in the FIP virus. An experimental drug called GS-441524 was used in a field experiment of 31 cats. After 25 days, five cats had...

intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue...

Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient...

Victoria C.; Muller, Florian L. (2020). "Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment". ACS Medicinal Chemistry Letters...

which treatment is generally symptomatic and palliative only. The drug GS-441524 shows promise as an antiviral treatment for FIP, but at the moment it...

Gilead Sciences and remdesivir, and the potentially cheaper alternative GS-441524. In 1968, Nader recruited seven volunteer law students, dubbed "Nader's...

against Hepatitis C and remdesivir, an FDA approved drug against COVID- GS-441524 triphosphate is a substrate for RdRp, but not mammalian polymerases. It...

hydrobromide salt of this drug. The drug is a deuterated tri-isobutyrate of GS-441524, the active metabolite of remdesivir. It was first described in a November...

(self-immolation is the key principle of ProTide nucleotide prodrugs). Because GS-441524 nucleoside can be phosphorylated and activated, some researchers have...