hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This...
20 KB (2,337 words) - 22:05, 16 September 2024
Orphenadrine (category HERG blocker)
dopamine reuptake inhibitor) Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker HERG potassium channel blocker George Rieveschl was a professor of chemistry at...
18 KB (1,550 words) - 02:58, 26 October 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
116 KB (11,202 words) - 07:03, 1 November 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
80 KB (8,640 words) - 20:17, 27 October 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
62 KB (5,826 words) - 16:29, 30 September 2024
Terfenadine (category HERG blocker)
effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity...
9 KB (782 words) - 21:56, 16 September 2024
Astemizole (category HERG blocker)
fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade). Astemizole is a histamine H1-receptor antagonist. It has...
7 KB (522 words) - 16:34, 23 September 2024
Noribogaine (category HERG blocker)
does ibogaine. Noribogaine is a hERG inhibitor and appears at least as potent as ibogaine. The inhibition of the hERG potassium channel delays the repolarization...
10 KB (879 words) - 18:04, 21 October 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
44 KB (3,871 words) - 18:24, 30 October 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
181 KB (19,613 words) - 00:45, 31 October 2024