Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label. These conjugates are used in immunotherapy[citation...
2 KB (155 words) - 04:46, 13 August 2023
cBR96-doxorubicin immunoconjugate (BMS-182248/SGN-15; also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed to the Lewis-Y antigen...
3 KB (250 words) - 11:18, 22 April 2022
extremely toxic to all cells and, in 2000, a CD33 antigen-targeted immunoconjugate N-acetyl dimethyl hydrazide calicheamicin was developed and marketed...
16 KB (1,506 words) - 18:06, 10 February 2024
This study can be performed in vitro (reactivity of the antibody or immunoconjugate should be determined with a quick-frozen adult tissues) or in vivo...
119 KB (13,400 words) - 17:29, 29 August 2024
drug. Antibody–drug conjugates are an example of bioconjugates and immunoconjugates. ADCs combine the targeting properties of monoclonal antibodies with...
41 KB (4,305 words) - 11:56, 24 August 2024
Damle NK, Frost P (August 2003). "Antibody-targeted chemotherapy with immunoconjugates of calicheamicin". Current Opinion in Pharmacology. 3 (4): 386–390...
13 KB (1,246 words) - 02:44, 14 August 2024
ovarian cancer, malignant ascites, gastric cancer cBR96-doxorubicin immunoconjugate mab humanized Lewis-Y antigen cancer Cedelizumab mab humanized CD4...
137 KB (4,083 words) - 21:25, 19 October 2024
protein crosslinking to nucleic acids, but also in the preparation of immunoconjugates. EDC is often used in combination with N-hydroxysuccinimide (NHS) for...
9 KB (740 words) - 14:12, 3 October 2024
PMID 1330289. Safa, Malek; Foon, Kenneth A.; Oldham, Robert K. (2009). "Drug Immunoconjugates". In Oldham, Robert K.; Dillman, Robert O. (eds.). Principles of Cancer...
45 KB (4,451 words) - 16:57, 22 September 2024
(PDF). WHO Drug Information. 16 (1): 95. 2002. "labetuzumab-SN-38 immunoconjugate IMMU-130". National Cancer Institute: NCI Dictionaries. National Institutes...
2 KB (92 words) - 23:53, 17 July 2024