Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first identified as an inducer of neuritogenesis in neuroblastoma...

Lactacystin was licensed to Myogenics/Proscript, which was acquired by Millennium Pharmaceuticals, now part of Takeda Pharmaceuticals. Lactacystin covalently...

from the Ishigaki Island in Japan. Streptomyces cyslabdanicus produces lactacystin and cyslabdan. List of Streptomyces species Parte, A.C. "Genus Streptomyces"...

non-peptidic proteasome inhibitor discovered was the natural product lactacystin. Disulfiram has been proposed as another proteasome inhibitor....

prostaglandins. Other notable syntheses: Longifolene Ginkgolides A and B Lactacystin Miroestrol Ecteinascidin 743 Salinosporamide A Corey and his research...

of protein kinase named staurosporine; a proteasome inhibitor named lactacystin; a fatty acid biosynthesis inhibitor named cerulenin; Furthermore, compounds...

near lake from Inba in Japan. Streptomyces lactacystinicus produces lactacystin and cyslabdan. List of Streptomyces species Parte, A.C. "Genus Streptomyces"...

tumors. In 1995, Schreiber and co-workers found that the small molecule lactacystin binds and inhibits specific catalytic subunits of the proteasome, a protein...

PMID 10468620. Schwarz, K.; et al. (2000). "The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation...

natural products such as trichoviridin, acromelic acid A, hypoglycin A and lactacystin; and biomimetic synthesis of natural products such as (-)-xestospongin...