Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product that was first isolated from the actinobacterium Streptomyces...

provider-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium...

inhibitor lipstatin, of which the antiobesity drug orlistat is a derivative. Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor...

and is a more simple and stable compound than lipstatin. For that reason orlistat was chosen over lipstatin for development as an anti-obesity drug. It...