MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor...
18 KB (1,887 words) - 03:44, 24 July 2024
arises in the body as the toxic metabolite of the closely related compound MPTP. MPTP is converted in the brain into MPP+ by the enzyme MAO-B, ultimately causing...
17 KB (1,687 words) - 02:34, 13 May 2023
Substantia nigra (section MPTP)
substantia nigra). MPTP, is a neurotoxin specific to dopaminergic cells in the brain, specifically in the substantia nigra. MPTP was brought to the spotlight...
43 KB (5,078 words) - 18:54, 22 June 2024
The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of...
32 KB (3,440 words) - 20:29, 23 March 2024
transition pore (MPTP), thus preventing MPTP opening. The MPTP is found in the mitochondrial membrane of cardiac muscle cells. MPTP opening signifies...
57 KB (5,319 words) - 22:41, 15 August 2024
of PD. Risk is increased by co-exposure to, for example, glyphosate and MPTP. Harmful heavy metals include mainly manganese, iron, lead, mercury, aluminium...
169 KB (17,779 words) - 07:57, 15 August 2024
DSP-4 Oxidopamine (6-OHDA) Dopaminergic Fenpropathrin Methamphetamine MPP+ MPTP Norsalsolinol Oxidopamine (6-OHDA) Rotenone Salsolinol Serotonergic 3-CA...
166 KB (15,881 words) - 07:54, 15 August 2024
temperature. Consequently, MPTP was formed as a major impurity. 1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible...
10 KB (911 words) - 14:47, 26 April 2024
differentiation. 9-Me-BC also inhibited the oxidation of the neurotoxin precursor MPTP to the dopaminergic neurotoxin MPP+ in vitro. Rodent studies in vivo demonstrated...
7 KB (553 words) - 12:59, 12 April 2024
pathology to Parkinson's disease in aged rhesus monkeys from MPTP. Therefore, the mechanism behind MPTP as it relates to Parkinson's disease is not fully understood...
33 KB (3,451 words) - 13:57, 4 August 2024