MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor...

arises in the body as the toxic metabolite of the closely related compound MPTP. MPTP is converted in the brain into MPP+ by the enzyme MAO-B, ultimately causing...

substantia nigra). MPTP, is a neurotoxin specific to dopaminergic cells in the brain, specifically in the substantia nigra. MPTP was brought to the spotlight...

The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of...

transition pore (MPTP), thus preventing MPTP opening. The MPTP is found in the mitochondrial membrane of cardiac muscle cells. MPTP opening signifies...

of PD. Risk is increased by co-exposure to, for example, glyphosate and MPTP. Harmful heavy metals include mainly manganese, iron, lead, mercury, aluminium...

DSP-4 Oxidopamine (6-OHDA) Dopaminergic Fenpropathrin Methamphetamine MPP+ MPTP Norsalsolinol Oxidopamine (6-OHDA) Rotenone Salsolinol Serotonergic 3-CA...

temperature. Consequently, MPTP was formed as a major impurity. 1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible...

differentiation. 9-Me-BC also inhibited the oxidation of the neurotoxin precursor MPTP to the dopaminergic neurotoxin MPP+ in vitro. Rodent studies in vivo demonstrated...

pathology to Parkinson's disease in aged rhesus monkeys from MPTP. Therefore, the mechanism behind MPTP as it relates to Parkinson's disease is not fully understood...