Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing...
23 KB (2,312 words) - 20:35, 22 July 2024
Osteoclast (section Matrix metalloproteinases)
members of the cathepsin and matrix metalloprotease (MMP) groups, are released to digest the organic components of the matrix. These enzymes are released...
26 KB (2,925 words) - 20:28, 17 May 2024
Metalloproteinase (redirect from Metalloprotease)
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant...
7 KB (759 words) - 02:51, 1 April 2024
inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration...
11 KB (1,358 words) - 17:09, 6 September 2023
vesicles in pancreatic cancer. In turn, this impairs release of matrix metalloprotease enzymes in the tumor microenvironment, in turn slowing down metastasis...
19 KB (2,105 words) - 07:28, 26 May 2024
the basis of its two main development drugs: marimastat (a novel matrix metalloprotease inhibitor for cancer treatment) and lexipafant (Zacutex, for pancreatitis)...
7 KB (511 words) - 12:53, 30 January 2024
"Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and...
10 KB (1,179 words) - 03:53, 29 November 2023
Glycocalyx (redirect from Pericellular matrix)
by enzymes. Hyaluronidase, hepararanse/heparinase, matrix and membrane-type matrix metalloproteases, thrombin, plasmin and elastase are some examples of...
19 KB (2,192 words) - 08:58, 29 July 2024
the functions of matrix metalloproteases (MMPs) or metalloprotease-disintegrins (ADAMs) and natural tissue inhibitors of metalloproteases (TIMPs). Regulated...
42 KB (5,270 words) - 19:38, 15 February 2024
carcinoma of the breast. Plasmin can activate matrix metalloproteases (MMP's) in the extracellular matrix (ECM). MMP activation contributes to tumor cell...
9 KB (1,083 words) - 14:08, 27 January 2024