minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative...

72 polymorphisms, MDM2 SNP309, and A2164G may collectively be associated with non-oropharyngeal cancer susceptibility and that MDM2 SNP309 in combination...

can regulate cytosolic protein localization. For example, the E3 ligase MDM2 ubiquitylates p53 either for degradation (K48 polyubiquitin chain), or for...

unlike most neoplastic cell in the liposarcomas, do not overexpress the MDM2 gene); 2) atypical spindle cell lipomas (i.e. benign tumors with mildly atypical...

investigational new drug that is being evaluated to treat liposarcoma. It is a MDM2 inhibitor. "Milademetan - Rain Oncology". AdisInsight. Springer Nature Switzerland...

Journal of medicinal chemistry, 2003 Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth...

SWI/SNF complex assembly pathway. The protein domain, SWIB/MDM2, short for SWI/SNF complex B/MDM2 is an important domain. This protein domain has been found...

accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting...

Brigimadlin (BI-907828) is a small molecule MDM2-TP53 inhibitor developed for liposarcoma. "Brigimadlin". pubchem.ncbi.nlm.nih.gov. Rinnenthal, Joerg;...

cancer HRAS 30% KRAS 20% MYB 15–20% Esophageal cancer MYC 40% CCND1 25% MDM2 13% Gastric cancer CCNE (Cyclin E) 15% KRAS 10% MET 10% Glioblastoma ERBB1...