Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells as well as in hepatocytes. Specifically, it appears...
6 KB (690 words) - 18:46, 27 April 2024
reported and are included as warnings on the label for ezetimibe. Since NPC1L1 also regulates vitamin K uptake, the use of ezetimibe can lead to side effects...
20 KB (1,819 words) - 11:14, 1 July 2024
K2 from foods. The intestinal membrane protein Niemann–Pick C1-like 1 (NPC1L1) mediates cholesterol absorption. Animal studies show that it also factors...
69 KB (7,760 words) - 11:23, 19 August 2024
Ezetimibe/rosuvastatin combines two lipid-lowering therapies. Ezetimibe inhibits NPC1L1, the transporter that is responsible for absorption of dietary cholesterol...
8 KB (387 words) - 04:18, 6 July 2024
PMID 24752831. Liao J, Yang L, Zhou L, Zhao H, Qi X, Cui Y, Ouyang D (2022). "The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein...
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by decreasing the absorption of cholesterol in the GI tract by targeting NPC1L1, a transport protein in the gastrointestinal wall. This results in decreased...
37 KB (3,520 words) - 14:53, 19 February 2024
P48145 10715 NPBWR2 HGNC:4530 P48146 10716 NPC1 HGNC:7897 O15118 10717 NPC1L1 HGNC:7898 Q9UHC9 10718 NPC2 HGNC:14537 P61916 10719 NPDC1 HGNC:7899 Q9NQX5...
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hypertension. Thornberry also helped to identify Niemann-Pick C1-Like 1 (NPC1L1) as the target of ezetimibe, an inhibitor of cholesterol absorption. In...
19 KB (1,718 words) - 02:14, 14 August 2024
SCH-48461 is a cholesterol absorption inhibitor. During the early phases of an NPC1L1 inhibitor discovery program at Schering-Plough, conformationally restricted...
4 KB (251 words) - 02:50, 4 May 2021
PPARdelta activation coincides with decreased intestinal expression of NPC1L1". Journal of Lipid Research. 46 (3): 526–534. doi:10.1194/jlr.M400400-JLR200...
18 KB (1,963 words) - 18:29, 24 August 2024