Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells as well as in hepatocytes. Specifically, it appears...

reported and are included as warnings on the label for ezetimibe. Since NPC1L1 also regulates vitamin K uptake, the use of ezetimibe can lead to side effects...

K2 from foods. The intestinal membrane protein Niemann–Pick C1-like 1 (NPC1L1) mediates cholesterol absorption. Animal studies show that it also factors...

Ezetimibe/rosuvastatin combines two lipid-lowering therapies. Ezetimibe inhibits NPC1L1, the transporter that is responsible for absorption of dietary cholesterol...

PMID 24752831. Liao J, Yang L, Zhou L, Zhao H, Qi X, Cui Y, Ouyang D (2022). "The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein...

by decreasing the absorption of cholesterol in the GI tract by targeting NPC1L1, a transport protein in the gastrointestinal wall. This results in decreased...

P48145 10715 NPBWR2 HGNC:4530 P48146 10716 NPC1 HGNC:7897 O15118 10717 NPC1L1 HGNC:7898 Q9UHC9 10718 NPC2 HGNC:14537 P61916 10719 NPDC1 HGNC:7899 Q9NQX5...

hypertension. Thornberry also helped to identify Niemann-Pick C1-Like 1 (NPC1L1) as the target of ezetimibe, an inhibitor of cholesterol absorption. In...

SCH-48461 is a cholesterol absorption inhibitor. During the early phases of an NPC1L1 inhibitor discovery program at Schering-Plough, conformationally restricted...

PPARdelta activation coincides with decreased intestinal expression of NPC1L1". Journal of Lipid Research. 46 (3): 526–534. doi:10.1194/jlr.M400400-JLR200...