The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants...
13 KB (1,234 words) - 02:29, 15 August 2024
and other behaviours. There are two types of orexin peptide and two types of orexin receptor. Orexin was discovered in 1998 almost simultaneously by...
54 KB (6,141 words) - 03:36, 18 August 2024
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...
19 KB (1,978 words) - 11:32, 1 May 2024
Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...
10 KB (1,104 words) - 02:20, 10 March 2024
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. It...
17 KB (1,672 words) - 02:28, 15 August 2024
Somnifacient (section Dual orexin receptor antagonist)
Dual orexin receptor antagonists are drugs that block the orexin receptors OX1 and OX2, hence reducing the wakeful effect of the orexin system and inducing...
27 KB (2,930 words) - 09:17, 7 May 2024
Suvorexant (category Orexin antagonists)
Suvorexant is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin OX1 and OX2 receptors. The medication has...
94 KB (8,956 words) - 03:07, 14 August 2024
Lemborexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Lemborexant has...
21 KB (1,687 words) - 04:21, 27 January 2024
Daridorexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Daridorexant...
48 KB (4,078 words) - 11:27, 24 July 2024
cycles. Once made, the orexin peptides can bind to the orexin receptor; which is a G protein-coupled receptor. This receptor senses molecules outside...
5 KB (653 words) - 05:33, 8 December 2023