Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded...
25 KB (3,073 words) - 13:49, 19 July 2024
PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins...
31 KB (3,266 words) - 05:29, 20 May 2024
Programmed cell death protein 1 (redirect from PD-1)
superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2. In a screen for genes involved in apoptosis, Yasumasa...
39 KB (5,010 words) - 21:07, 27 June 2024
who cannot receive cisplatin-based chemotherapy and have high levels of PD-L1, as a second-line treatment for head and neck squamous cell carcinoma (HNSCC)...
79 KB (7,328 words) - 01:51, 16 July 2024
first PD-L1 inhibitor approved by the U.S. for bladder cancer. Food and Drug Administration (FDA). In the European Union, atezolizumab is the first PD-(L)1...
43 KB (4,164 words) - 02:04, 16 July 2024
Checkpoint inhibitor (section PD-L1 inhibitors)
CTLA4, PD-1, and PD-L1. PD-1 is the transmembrane programmed cell death 1 protein (also called PDCD1 and CD279), which interacts with PD-L1 (PD-1 ligand...
21 KB (2,093 words) - 18:53, 25 January 2024
Cancer immunotherapy (redirect from PD-1 inhibitor)
programmed cell death 1 protein (PDCD1, PD-1; also known as CD279) and its ligand, PD-1 ligand 1 (PD-L1, CD274). PD-L1 on the cell surface binds to PD1 on...
89 KB (10,338 words) - 14:21, 16 July 2024
NSCLC cells expressing programmed death-ligand 1 (PD-L1) could interact with programmed death receptor 1 (PD-1) expressed on the surface of T cells, and result...
50 KB (5,298 words) - 14:20, 11 August 2024
exploit the PD-1 pathway to shield themselves from the immune response by expressing programmed death-ligand 1 (PD-L1), which interacts with the PD-1 receptor...
47 KB (4,870 words) - 15:14, 3 August 2024
treatments. The first interim results show promise for combined TIGIT and PD-L1 co-blockade in solid cancer patients. Mechanistically, research has shown...
18 KB (2,103 words) - 17:00, 19 July 2024