• Thumbnail for P110α
    P110α (redirect from PIK3CA)
    PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene...
    17 KB (1,929 words) - 02:08, 3 December 2023
  • PIK3CA-related overgrowth spectrum (PROS) is an umbrella term for rare syndromes characterized by malformations and tissue overgrowth caused by somatic...
    5 KB (487 words) - 20:17, 23 February 2022
  • Thumbnail for Facial infiltrating lipomatosis
    overgrowth condition caused by a genetic mutation of the PIK3CA gene. The condition is a part of the PIK3CA related overgrowth spectrum (PROS). The disease is...
    7 KB (781 words) - 15:29, 3 February 2022
  • Thumbnail for Alpelisib
    (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved...
    15 KB (958 words) - 05:40, 18 July 2024
  • Thumbnail for CLOVES syndrome
    somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related overgrowth syndromes (PROS). This rare condition...
    7 KB (712 words) - 07:47, 13 October 2023
  • Thumbnail for PI3K/AKT/mTOR pathway
    common genomic abnormalities. The most common known aberrations include the PIK3CA gene mutation and the loss-of-function mutations or epigenetic silencing...
    36 KB (4,322 words) - 11:55, 11 August 2024
  • only 120 people worldwide, but more recent diagnoses have focused on a PIK3CA gene mutation. Some reports still describe her condition as a rare form...
    6 KB (747 words) - 18:32, 3 July 2024
  • Thumbnail for Phosphoinositide 3-kinase
    inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer...
    32 KB (3,463 words) - 17:34, 20 November 2023
  • political party, Portuguese name: Partido Republicano da Ordem Social PROS (PIK3CA-related overgrowth spectrum), a form of tissue overgrowth Pro (disambiguation)...
    439 bytes (80 words) - 11:49, 3 October 2018
  • Thumbnail for Inavolisib
    inavolisib in combination with palbociclib and fulvestrant in patients that have PIK3CA-mutated, locally advanced or metastatic, hormone receptor-positive, HER2-negative...
    21 KB (2,184 words) - 23:28, 5 August 2024