of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6...
17 KB (1,895 words) - 07:46, 3 June 2024
groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains...
62 KB (6,833 words) - 02:25, 22 June 2024
of SLE. Other genes that contain risk variants for SLE are IRF5, PTPN22, STAT4, CDKN1A, ITGAM, BLK, OX40L and BANK1. Some of the susceptibility genes may...
119 KB (13,047 words) - 02:23, 25 July 2024
important in activating critical transcription factor proteins such as STAT4 that are implicated in IL-12 signaling in T cells and NK cells. This pathway...
14 KB (1,578 words) - 14:00, 26 February 2024
pro-inflammatory cytokines, including TNFα. Possible gene polymorphism: STAT4, PTPN2, PSORS1C1 and TRAF3IP2 genes had been correlated with response to...
147 KB (17,113 words) - 14:30, 9 July 2024
and Tyrosine kinase 2 transduce the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate transcription of target genes in nucleus. STAT3...
20 KB (2,192 words) - 23:02, 27 November 2023
IgG B cells, and IFN-γ CD4 T cells. The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose...
54 KB (6,597 words) - 14:51, 21 July 2024
ENSG00000168610 STAT Known motif – In vivo/Misc source [887] HTTCCYRKMA STAT4 ENSG00000138378 STAT Known motif – In vivo/Misc source [888] BDHTTCTBGKAAD...
374 KB (81 words) - 02:10, 23 September 2023
SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK...
13 KB (1,341 words) - 04:09, 6 March 2024
and craniosynostosis syndromes Stat3 Lethal Tissue specific phenotypes Stat4 Viable defective IL-12-driven Th1 differentiation, increased susceptibility...
46 KB (4,967 words) - 21:12, 7 July 2024