Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription...
18 KB (2,073 words) - 05:43, 22 July 2024
initiates a STAT6 signalling response. Binding of IL-13 causes phosphorylation of tyrosine residues at the IL-4Rα. This results in docking of STAT6 monomers...
20 KB (2,271 words) - 04:25, 12 May 2024
are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains, each with a different function...
62 KB (6,845 words) - 18:30, 22 August 2024
the type 2 IL-4 receptor. Heterodimerization activates both the STAT6 and the IRS. STAT6 signaling is important in initiation of the allergic response....
24 KB (3,043 words) - 22:14, 16 June 2024
mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and...
23 KB (2,748 words) - 13:53, 21 January 2024
regeneration cascade through phosphorylation of its intracellular effector STAT6 in an experimental Alzheimer's disease model in adult zebrafish brain. IL-4...
19 KB (2,293 words) - 11:05, 8 March 2024
tried to map susceptibility genes for atopy. Genes for atopy (C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1/IL18R1, TLR1/TLR6/TLR10, LPP, MYC/PVT1, IL2/ADAD1...
24 KB (2,561 words) - 17:54, 7 July 2024
proliferation, and, in ≤15% of cases several other genes including MEF2B, STAT6, EP300, ARID1A, SLC22A2, CARD11, FOXO1, GNA12, B2M (i.e. the gene for beta-2...
67 KB (7,967 words) - 20:38, 20 July 2024
Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous...
7 KB (645 words) - 15:26, 6 November 2023
and drugs which are inhibitors of the enzyme. Competition studies between STAT6 and inhibitors have used ESI as a way to screen for potential new drug candidates...
45 KB (5,340 words) - 11:37, 24 July 2024