subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene. 9-Phenanthrol TRPM4-IN-5 TRPM GRCh38:...
4 KB (465 words) - 23:05, 16 July 2024
TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC50 of 1.5μM. It is protective against...
2 KB (126 words) - 01:50, 4 February 2024
that consists of extrasynaptic NMDA receptor and TRPM4. Disruption of this complex using NMDAR/TRPM4 interface inhibitors (also known as ‚interface inhibitors‘)...
25 KB (2,788 words) - 23:34, 3 December 2023
channel subfamily M member 4 (TRPM4). The NMDAR/TRPM4 complex is considered central to glutamate excitotoxicity. NMDAR/TRPM4 interaction interface inhibitors...
6 KB (630 words) - 14:34, 22 November 2022
permeability of calcium and magnesium varies widely among TRPM channels. TRPM4 and TRPM5 are impermeable to calcium. TRPM3, TRPM6 and TRPM7 are highly...
7 KB (821 words) - 22:40, 16 July 2024
Osmotherapy (section SUR1/ TRPM4)
cerebral edema at a molecular level. Targets identified includes: NKCC1, SUR1/ TRPM4 channel, Vasopressin receptor antagonist. During early and reperfusion stage...
17 KB (2,050 words) - 06:15, 27 December 2023
2022). "Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia". Molecular Neurobiology...
15 KB (1,138 words) - 19:51, 31 July 2024
acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5...
14 KB (1,416 words) - 12:13, 14 July 2024
acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5...
61 KB (6,561 words) - 12:55, 11 August 2024
among others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major clades...
49 KB (5,517 words) - 22:16, 16 July 2024