In genetics, trinucleotide repeat disorders, a subset of microsatellite expansion diseases (also known as repeat expansion disorders), are a set of over...
26 KB (2,709 words) - 18:38, 5 July 2024
A trinucleotide repeat expansion, also known as a triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized...
61 KB (7,973 words) - 04:54, 27 May 2024
Anticipation (genetics) (category Genetic disorders by mechanism)
severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders, such as Huntington's disease and myotonic dystrophy, where...
5 KB (710 words) - 20:32, 5 December 2023
the most commonly observed manifestations of this process. Trinucleotide repeat disorders also follow a non-Mendelian pattern of inheritance. These diseases...
22 KB (2,627 words) - 12:41, 24 August 2024
Huntington's disease (category Trinucleotide repeat disorders)
influenced by the sex of the affected parent. HD is one of several trinucleotide repeat disorders that are caused by the length of a repeated section of a gene...
137 KB (14,365 words) - 00:39, 26 August 2024
Dentatorubral–pallidoluysian atrophy (category Trinucleotide repeat disorders)
caused by expanded CAG repeats encoding polyglutamine (polyQ) stretches (see: Trinucleotide repeat disorder). The expanded CAG repeats create an adverse gain-of-function...
23 KB (2,513 words) - 09:06, 10 July 2024
Microsatellite (redirect from Short tandem repeat)
disorder in humans. Length changes in other triplet repeats are linked to more than 40 neurological diseases in humans, notably trinucleotide repeat disorders...
67 KB (7,393 words) - 17:16, 28 June 2024
Myotonic dystrophy (category Trinucleotide repeat disorders)
(CTG) triplet repeats, termed trinucleotide repeat expansion and classifying DM1 as one of several trinucleotide repeat disorders. This expansion occurs...
43 KB (4,556 words) - 18:30, 1 August 2024
chromosome extra, missing, or both (see chromosome abnormality) T – Trinucleotide repeat disorders: gene is extended in length "OMIM Entry - # 118220 - CHARCOT-MARIE-TOOTH...
42 KB (983 words) - 10:34, 21 August 2024
called a trinucleotide repeat (for example: CAGCAGCAGCAG...), and abnormalities in such regions can give rise to trinucleotide repeat disorders. When between...
10 KB (1,118 words) - 16:49, 12 July 2024