BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for...

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these...

or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and BRCA2 have...

whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier...

or ovaries, or sex steroid-responsive genes. Breast cancer caused by the BRCA2 mutation is an example of a disease with gender-related penetrance. The...

cancer gene, BRCA2, and related proteins cause genome instability to trigger carcinogenesis. His work has helped to explain why carriers of BRCA2 mutations...

related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the disease. Some family cancer syndromes...

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene. This gene encodes a protein that...

homologous recombination. The well-known cancer susceptibility genes BRCA1 and BRCA2 are also examples of FA genes (FANCS and FANCD1 respectively), and biallelic...

suppressing BRCA2 gene), which can increase the risk of a woman developing ovarian cancer to as high as 65% (as high as 25% for a mutated BRCA2 gene). List...