11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene...
25 KB (2,818 words) - 22:50, 12 May 2024
to be associated with the mutation. On chromosome 19, the gene known as STK11 (LKB1) is a possible tumor suppressor gene. It is inherited in an autosomal...
16 KB (1,611 words) - 19:55, 23 August 2024
convergence driven by admixture (e.g., MTHFD1 and RAD18), new mutations (e.g., STK11), or notably purifying selection (e.g., MC1R). Endicott, Phillip; Gilbert...
20 KB (2,148 words) - 07:16, 25 August 2024
STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein). CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic...
5 KB (626 words) - 20:57, 3 March 2023
rare hereditary syndromes: Peutz–Jeghers syndrome due to mutations in the STK11 tumor suppressor gene (very rare, but a very strong risk factor); dysplastic...
122 KB (12,761 words) - 21:58, 27 August 2024
often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of lung tumors...
3 KB (232 words) - 04:56, 19 May 2024
CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1...
45 KB (4,650 words) - 10:29, 24 August 2024
CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1...
65 KB (7,149 words) - 04:45, 26 August 2024
dominant 1:10,000 Pendred syndrome PDS (7) recessive Peutz–Jeghers syndrome STK11 dominant 1:25,000-300,000 Pfeiffer syndrome FGFR1, FGFR2 dominant 1:100...
42 KB (983 words) - 10:34, 21 August 2024
CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1...
119 KB (12,654 words) - 00:05, 31 July 2024