Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a...

Werner syndrome (WS) or Werner's syndrome, also known as "adult progeria", is a rare, autosomal recessive disorder which is characterized by the appearance...

Sopher BL, Martin GM, et al. (September 1997). "The Werner syndrome protein is a DNA helicase". Nature Genetics. 17 (1): 100–103. doi:10.1038/ng0997-100...

DNA helicase family. Mutations in genes encoding other members of this family, namely WRN and RECQL4, are associated with the clinical entities Werner syndrome...

if not repaired. This is exemplified by the dependency of the Werner syndrome helicase in MSI-H cancers. Microsatellite instability is associated with...

in RecQ helicases; thus it is crucial that RecQ is present and functional to ensure proper human growth and development. The Werner syndrome ATP-dependent...

connected to Werner syndrome. WRN encodes the WRNp protein, a 1432 amino acid protein with a central domain resembling members of the RecQ helicases. WRNp is...

disorder, Werner syndrome". Mutat. Res. 577 (1–2): 252–9. doi:10.1016/j.mrfmmm.2005.03.021. PMID 15916783. Monnat RJ (2010). "Human RECQ helicases: roles...

DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs...

mutations in the DNA helicase RECQL4 gene, causing problems during initiation of DNA replication has been implicated in the syndrome. Sun-sensitive rash...