opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene. PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending...
38 KB (4,865 words) - 20:29, 3 December 2023
the gene PKLR, whereas the M1 and M2 isozymes are expressed by the gene PKM2. The R and L isozymes differ from M1 and M2 in that they are allosterically...
33 KB (4,042 words) - 02:51, 1 February 2024
Tumor M2-PK (section Tetrameric and dimeric PKM2)
a synonym for the dimeric form of the pyruvate kinase isoenzyme type M2 (PKM2), a key enzyme within tumor metabolism. Tumor M2-PK can be elevated in many...
17 KB (2,307 words) - 01:55, 28 March 2024
cells. A-Raf upregulates the activity of PKM2 by promoting a conformational change in PKM2. This causes PKM2 to transition from its low-activity dimeric...
16 KB (1,985 words) - 12:57, 29 July 2023
tumorigenesis. Lu demonstrated that glycolytic enzyme pyruvate kinase M2 (PKM2) acts as a protein kinase and phosphorylates histone H3 to epigenetically...
18 KB (1,876 words) - 10:49, 20 August 2023
Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity, https://www.frontiersin.org/articles/10...
33 KB (3,707 words) - 21:44, 12 September 2024
paradigm. The discovery of the involvement of particular enzymes such as PKM2, mutated IDH as well as novel oncometabolites such as 2-hydroxyglutarate...
18 KB (1,659 words) - 07:46, 13 September 2024
following lines: Poznań Główny – Kutno (Part of Poznań suburban rail Line PKM2 between Poznań Główny and Września) Poznań Główny – Mogilno (Part of Poznań...
9 KB (326 words) - 17:19, 21 June 2023
metabolism was likely to vary across different forms of cancer; however, PKM2 was identified in all of the cancer cells they had tested. This enzyme form...
26 KB (3,172 words) - 03:56, 1 September 2024
of SLC38A3, a transporter for amino acids, and Aldoa, Eno1, Ldh1, Pfkp, Pkm2, and Tpi1, enzymes responsible for glycolysis. MGCs are more steroidogenically...
9 KB (1,141 words) - 12:40, 2 August 2024