DNA repair protein XRCC4 (hXRCC4) also known as X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. XRCC4...
43 KB (5,681 words) - 00:50, 14 June 2024
NHEJ, DNA Ligase IV, a specialized DNA ligase that forms a complex with the cofactor XRCC4, directly joins the two ends. To guide accurate repair, NHEJ...
129 KB (15,900 words) - 06:12, 13 August 2024
TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa) is a protein that in humans is encoded by the TARDBP gene. TDP-43...
41 KB (4,641 words) - 14:41, 30 July 2024
mitochondria. DNA ligase 4: complexes with XRCC4. It catalyzes the final step in the non-homologous end joining DNA double-strand break repair pathway. It...
23 KB (2,787 words) - 00:53, 18 June 2024
factors, such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein 4 (XRCC4) to form a bridge...
34 KB (4,130 words) - 03:55, 5 August 2024
break repair. It is also essential for V(D)J recombination. Lig4 forms a complex with XRCC4, and further interacts with the DNA-dependent protein kinase...
15 KB (1,821 words) - 05:44, 11 June 2024
lesion in DNA. This DNA adduct is removed by the repair protein O6-alkylguanine DNA alkyltransferase through an SN2 mechanism. This protein is not a true...
32 KB (3,857 words) - 22:04, 28 July 2024
step in the NHEJ pathway that requires DNA ligase activity of Dnl4-Lif1/XRCC4 heterodimer and the Nej1/XLF protein. This process results in error-prone...
18 KB (2,277 words) - 13:23, 26 November 2023
when DNA-PK binds to each broken DNA end and recruits several other proteins including Artemis, XRCC4, DNA ligase IV, Cernunnos, and several DNA polymerases...
21 KB (2,860 words) - 07:32, 14 March 2024
Non-homologous end joining (category DNA repair)
of the catalytic subunit DNA ligase IV and its cofactor XRCC4 (Dnl4 and Lif1 in yeast), performs the ligation step of repair. XLF, also known as Cernunnos...
28 KB (3,683 words) - 04:20, 22 August 2024