• Gene knockouts (also known as gene deletion or gene inactivation) are a widely used genetic engineering technique that involves the targeted removal or...
    21 KB (2,528 words) - 23:51, 28 October 2024
  • relate to human physiology. Gene knockout in rats is much harder and has only been possible since 2003. The first recorded knockout mouse was created by Mario...
    15 KB (1,889 words) - 15:09, 11 September 2024
  • Conditional gene knockout is a technique used to eliminate a specific gene in a certain tissue, such as the liver. This technique is useful to study the...
    9 KB (1,292 words) - 05:52, 19 December 2023
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    Human genome (redirect from Human gene pool)
    disease. In humans, gene knockouts naturally occur as heterozygous or homozygous loss-of-function gene knockouts. These knockouts are often difficult...
    99 KB (10,142 words) - 15:38, 13 October 2024
  • parent. It is used in horticulture, animal breeding, and production of gene knockout organisms. Backcrossed hybrids are sometimes described with acronym...
    7 KB (849 words) - 04:48, 3 January 2024
  • knock-in involves a gene inserted into a specific locus, and is thus a "targeted" insertion. It is the opposite of gene knockout. A common use of knock-in...
    13 KB (1,572 words) - 10:28, 7 November 2024
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    interference (RNAi) do not fully suppress gene function, CRISPR, ZFNs, and TALENs provide full, irreversible gene knockout. CRISPR can also target several DNA...
    170 KB (19,892 words) - 19:10, 3 November 2024
  • Thumbnail for Knockout rat
    A knockout rat is a genetically engineered rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical...
    23 KB (3,268 words) - 16:33, 6 April 2024
  • Thumbnail for Mupirocin
    C16. Gene knockout experiments of mupO, mupU, mupV, and macpE have eliminated PA-A production. PA-B production is not removed by these knockouts, demonstrating...
    30 KB (2,609 words) - 04:22, 27 October 2024
  • Thumbnail for Genetic engineering
    such as in a gene knockout experiment, in which an organism is engineered to lack the activity of one or more genes. In a simple knockout a copy of the...
    134 KB (14,252 words) - 10:01, 5 November 2024