Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a...
29 KB (3,448 words) - 01:15, 19 February 2024
and integrative vectors like lentiviral vectors are commonly employed for gene therapy. Chimeric viral vectors—such as hybrid vectors with qualities of...
48 KB (5,530 words) - 18:25, 28 June 2024
used in clinical and research settings, pioneering lentivirals vector in gene therapy. Jesse Gelsinger's death in 1999 impeded gene therapy research in the...
174 KB (17,957 words) - 10:42, 6 August 2024
Gene therapy using lentiviral vectors was being explored in early stage trials as of 2009.[needs update] In a Phase I clinical trial of three patients...
11 KB (1,503 words) - 11:37, 18 July 2024
CAR T cell (redirect from CAR T-cell therapy)
express a specific CAR, using a vector derived from an engineered lentivirus such as HIV (see Lentiviral vector in gene therapy). The CAR programs the T cells...
83 KB (8,682 words) - 19:28, 21 August 2024
(2014). "Long-term safety and tolerability of Pro Savin, a lentiviral vector-based gene therapy for Parkinson's disease: A dose escalation, open-label, phase...
14 KB (1,828 words) - 17:27, 24 May 2024
hosts, and extended gene expression. Lentiviral vectors have also shown promise. Among challenges to clinical translation of gene therapy are possible immune...
24 KB (2,918 words) - 07:12, 8 May 2024
organism. Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and...
25 KB (2,878 words) - 19:30, 14 August 2024
Lentivirus (redirect from Lentiviral)
platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has advantages over other gene-therapy methods including high-efficiency...
16 KB (1,770 words) - 21:42, 20 July 2024
Thalassemia (redirect from Gene therapy for thalassemia)
Emmanuel (February 2016). "Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β – Gene". Human Gene Therapy. 27 (2): 148–165. doi:10...
67 KB (7,150 words) - 08:45, 19 August 2024