• Thumbnail for MTORC1
    mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a...
    69 KB (7,807 words) - 19:19, 19 September 2024
  • Thumbnail for MTOR inhibitors
    and proliferation by forming and signaling through two protein complexes, mTORC1 and mTORC2. The most established mTOR inhibitors are so-called rapalogs...
    57 KB (6,280 words) - 19:28, 19 September 2024
  • Thumbnail for David M. Sabatini
    his lab discovered the mTORC1 and mTORC2 multi-protein complexes, the nutrient sensing Rag GTPase pathway upstream of mTORC1, as well as the direct amino...
    21 KB (2,070 words) - 09:22, 6 October 2024
  • Thumbnail for RHEB
    proliferation. RHEB localizes at the lysosome to activate mTORC1 and Rag7 proteins localize mTORC1 to the lysosome and the Ragulator-Rag complex, allowing...
    22 KB (2,661 words) - 15:23, 11 April 2024
  • Thumbnail for NV-5138
    complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway...
    7 KB (550 words) - 19:05, 6 May 2024
  • Thumbnail for MTOR
    MTOR (section mTORC1)
    mTOR is the catalytic subunit of two structurally distinct complexes: mTORC1 and mTORC2. The two complexes localize to different subcellular compartments...
    119 KB (12,658 words) - 19:25, 19 September 2024
  • Thumbnail for Everolimus
    mTORC1 protein complex, with little impact on the mTORC2 complex. This can lead to a hyper-activation of the kinase AKT via inhibition on the mTORC1 negative...
    27 KB (2,534 words) - 20:49, 4 October 2024
  • Thumbnail for Ragulator-Rag complex
    and Rag C/Rag D. These interact to form heterodimers with one another. mTORC1 is a complex within the lysosome membrane that initiates growth when promoted...
    14 KB (1,728 words) - 19:07, 25 October 2023
  • Thumbnail for Leucine
    up-regulation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), a signaling cascade involved in coordination of translation initiation...
    27 KB (4,132 words) - 00:11, 7 September 2024
  • Thumbnail for Cell proliferation
    metabolism, which is responsible for cell proliferation, can be regulated by mTORC1 signaling. In addition, intake of nutrients in animals can induce circulating...
    5 KB (646 words) - 20:04, 5 January 2024