Toll-like receptor 4 (redirect from TLR4)
against bacterial infections. TLR4 is a transmembrane protein of approximately 95 kDa that is encoded by the TLR4 gene. TLR4 belongs to the toll-like receptor...
75 KB (9,082 words) - 10:46, 12 June 2024
which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Humans lack...
61 KB (6,763 words) - 10:28, 1 August 2024
TLR4-IN-C34 (or C34) is a drug which acts as a potent and selective antagonist of Toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated...
3 KB (302 words) - 08:16, 17 February 2024
known to induce inflammation by activating NF-κB pathway by binding to TLR, TLR4, TLR9, and RAGE (receptor for advanced glycation end products). HMGB1 can...
35 KB (3,558 words) - 10:17, 24 July 2024
A. Primarily, TLR4 is required for activation of innate immunity upon recognition of LPS of Gram-negative bacteria. The ability of TLR4/MD-2 system to...
12 KB (1,377 words) - 01:48, 11 December 2023
Eritoran is a synthetic lipid that inhibits the receptor TLR4. It was developed as a potential treatment for severe sepsis, an excessive inflammatory response...
7 KB (417 words) - 17:55, 4 November 2023
through the bonding with TLR4, causing them to proliferate in reaction to a systemic infection. This response activate the TLR4-TRIF-ROS-p38 signaling within...
63 KB (7,188 words) - 10:03, 16 July 2024
receptor 4 (TLR4), which due to not binding to opioid receptors allows it to effectively reverse the analgesic properties of (−)-morphine. TLR4 is involved...
3 KB (302 words) - 00:52, 18 February 2024
identify inhibitors of the receptor TLR4. It binds directly to cysteine residue 747 intracellularly, preventing TLR4 binding with TIRAP and thus preventing...
6 KB (595 words) - 20:34, 30 April 2024
potent and selective antagonist of toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects...
2 KB (161 words) - 23:56, 26 July 2023