protein XRCC4 (hXRCC4) also known as X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. XRCC4 is also...
43 KB (5,681 words) - 00:50, 14 June 2024
cross-complementing protein 4 (XRCC4), DNA ligase IV, non-homologous end-joining factor 1 (NHEJ1; also known as Cernunnos or XRCC4-like factor [XLF]), the recently...
21 KB (2,860 words) - 07:32, 14 March 2024
complex, consisting of the catalytic subunit DNA ligase IV and its cofactor XRCC4 (Dnl4 and Lif1 in yeast), performs the ligation step of repair. XLF, also...
28 KB (3,683 words) - 04:20, 22 August 2024
It is also essential for V(D)J recombination. Lig4 forms a complex with XRCC4, and further interacts with the DNA-dependent protein kinase (DNA-PK) and...
15 KB (1,821 words) - 05:44, 11 June 2024
Non-homologous end-joining factor 1 (NHEJ1), also known as Cernunnos or XRCC4-like factor (XLF), is a protein that in humans is encoded by the NHEJ1 gene...
13 KB (1,652 words) - 12:24, 7 November 2023
double-strand breaks where it acts as a scaffold for the recruitment of the XRCC4-DNA ligase protein complex that then acts to repair double-strand breaks...
21 KB (2,137 words) - 22:21, 9 July 2024
WRN protein also physically interacts with the major NHEJ factor X4L4 (XRCC4-DNA ligase 4 complex). X4L4 stimulates WRN exonuclease activity that likely...
36 KB (4,516 words) - 19:56, 23 August 2024
been found to be present in mitochondria. DNA ligase 4: complexes with XRCC4. It catalyzes the final step in the non-homologous end joining DNA double-strand...
23 KB (2,787 words) - 00:53, 18 June 2024
subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein 4 (XRCC4) to form a bridge and bring both ends of the damaged DNA strands together...
34 KB (4,130 words) - 03:55, 5 August 2024
in growth and survival of cancer cells. These substrates include DEPTOR, XRCC4, SHOC2, SKP2, β-Catenin, MSX2, Nf1, c-Jun, IκBα, Erbin, NOXA, ASCT2, and...
10 KB (1,133 words) - 13:43, 23 June 2024