CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell...
28 KB (2,797 words) - 01:48, 26 March 2024
checkpoint. CHEK2 regulates cell cycle progression and spindle assembly during mouse oocyte maturation and early embryo development. Although CHEK2 is a down...
26 KB (3,047 words) - 02:53, 3 December 2023
downstream targets FANCD2 and FANCI. ATM activates (phosphorylates) CHEK2 and FANCD2 CHEK2 phosphorylates BRCA1. Ubiquinated FANCD2 complexes with BRCA1 and...
37 KB (4,140 words) - 08:44, 11 April 2024
and ovarian cancer. A recent study of the genes ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2 and TP53 found 15,311 DNA sequence variants in only 102 patients...
23 KB (2,275 words) - 11:29, 23 June 2024
kinase inhibitor, mainly active against CHEK1, with minor activity against CHEK2. This causes induction of DNA double-strand breaks resulting in apoptosis...
3 KB (107 words) - 11:55, 2 August 2023
early-onset prostate cancer – including BRCA1, ATM, NBS1, MSH2, MSH6, PMS2, CHEK2, RAD51D, and PALB2. Additionally, variants in the genome near the oncogene...
76 KB (8,857 words) - 11:41, 22 July 2024
associated with ovarian cancer are BRIP1, MSH6, RAD51C and RAD51D. CDH1, CHEK2, PALB2 and RAD50 have also been associated with ovarian cancer. Several...
196 KB (20,969 words) - 05:49, 19 July 2024
CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4...
46 KB (5,492 words) - 03:05, 21 June 2024
CDC42 effector protein 1 CECR1: cat eye syndrome critical region protein 1 CHEK2 (22q12) COMT CRELD2: cysteine-rich with EGF-like domain protein 2 CSDC2:...
27 KB (2,206 words) - 03:37, 10 March 2024
predisposition to breast cancer, intestinal cancer, and pancreatic cancer. CHEK2: Approximately one out of 40 northern Europeans have a mutation in this...
11 KB (1,135 words) - 03:45, 25 March 2024