increases the local Ca2+ concentration around the RyR, by a factor of 10. Calcium sparks can either be evoked or spontaneous, as described below. Electrical...

activation of the L-type calcium channel, via an action potential, activates the RyR directly, causing calcium release (see calcium sparks for more details)...

relationships between T-tubules and calcium release began to be unravelled with the discovery of calcium sparks. While early work focussed on ventricular...

known as calcium-induced calcium release and gives rise to calcium sparks (Ca2+ sparks). The spatial and temporal summation of ~30,000 Ca2+ sparks gives...

into the cytoplasm, also known as calcium sparks. This increase in calcium within the cell then activates a sodium-calcium exchanger (NCX), which removes...

release of further sparks from neighbouring ryanodine receptors to create an organised rise of calcium throughout the cell known as a calcium transient. At...

well-studied example of these are the "calcium sparks" that are produced for a short period in the region around an open calcium channel. These are about 2 micrometres...

regulator of sarcoplasmic release of stored calcium ions. It can reduce calcium sparks and thus arrhythmogenic calcium waves in the heart. While Flecainide therapy...

Ryanodine receptors (RyR for short) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons...

the detection of microscopic Ca2+ release events inside cells called "Calcium sparks". Whereas the salts of fluo-3 are unable to penetrate cells, loading...