mellitus. The major PDE5 inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share...

A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation...

hypertension. As of 2019, the wider cardiovascular benefits of PDE5 inhibitors are being appreciated. Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil...

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4)...

potential for selective phosphodiesterase inhibitors to be used as therapeutic agents was predicted in the 1970s by Weiss and coworkers. This prediction...

disorder (OCD), and migraine prevention. SNRIs are monoamine reuptake inhibitors; specifically, they inhibit the reuptake of serotonin and norepinephrine...

20–50% decrease in clearance. The inhibitors of CYP3A4 are the following substances. boceprevir, protease inhibitors: ritonavir, indinavir, nelfinavir...

Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and...

the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with...

and the forms imide, imido-, imid-, and imid. The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory...