Gene knockouts (also known as gene deletion or gene inactivation) are a widely used genetic engineering technique that involves the targeted removal or...
21 KB (2,524 words) - 18:03, 29 April 2024
Conditional gene knockout is a technique used to eliminate a specific gene in a certain tissue, such as the liver. This technique is useful to study the...
9 KB (1,292 words) - 05:52, 19 December 2023
relate to human physiology. Gene knockout in rats is much harder and has only been possible since 2003. The first recorded knockout mouse was created by Mario...
15 KB (1,889 words) - 14:59, 15 May 2024
Human genome (redirect from Human gene pool)
disease. In humans, gene knockouts naturally occur as heterozygous or homozygous loss-of-function gene knockouts. These knockouts are often difficult...
99 KB (10,152 words) - 15:40, 20 July 2024
A knockout rat is a genetically engineered rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical...
23 KB (3,268 words) - 16:33, 6 April 2024
knock-in involves a gene inserted into a specific locus, and is thus a "targeted" insertion. It is the opposite of gene knockout. A common use of knock-in...
12 KB (1,568 words) - 13:21, 31 December 2023
parent. It is used in horticulture, animal breeding, and production of gene knockout organisms. Backcrossed hybrids are sometimes described with acronym...
7 KB (849 words) - 04:48, 3 January 2024
C16. Gene knockout experiments of mupO, mupU, mupV, and macpE have eliminated PA-A production. PA-B production is not removed by these knockouts, demonstrating...
30 KB (2,604 words) - 23:12, 30 March 2024
interference (RNAi) do not fully suppress gene function, CRISPR, ZFNs, and TALENs provide full irreversible gene knockout. CRISPR can also target several DNA...
150 KB (17,422 words) - 14:03, 20 July 2024
types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first copied...
110 KB (12,568 words) - 07:41, 2 July 2024