hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This...
19 KB (2,330 words) - 07:03, 3 June 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
118 KB (11,372 words) - 21:46, 17 August 2024
dopamine reuptake inhibitor) Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker HERG potassium channel blocker George Rieveschl was a professor of chemistry at...
18 KB (1,550 words) - 11:17, 22 March 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
80 KB (8,530 words) - 10:23, 11 August 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
177 KB (18,939 words) - 07:46, 13 August 2024
Terfenadine (category HERG blocker)
effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity...
9 KB (782 words) - 13:17, 17 February 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
58 KB (5,556 words) - 18:57, 21 August 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
43 KB (3,828 words) - 22:00, 4 June 2024
Methadone (category HERG blocker)
other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone...
77 KB (7,776 words) - 12:25, 16 August 2024
Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid...
91 KB (8,944 words) - 03:28, 14 August 2024