Indolin-2-one monooxygenase (EC 1.14.13.138, BX3 (gene), CYP71C2 (gene)) is an enzyme with systematic name indolin-2-one,NAD(P)H:oxygen oxidoreductase...
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VEGFR-2 inhibitor (section Indolin derivatives)
potency and selectivity and gives an IC50 of 3nM against the receptor. Indolin derivatives on the market are Sunitinib and Intedanib. Two indol derivatives...
51 KB (4,735 words) - 08:15, 2 January 2024
industrial significance. The molecule consists of a pair of monobrominated indolin-3-one rings linked by a carbon-carbon double bond. It is produced by molluscs...
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W.T. (2018). "Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide". Synlett. 29 (2): 215–218. doi:10...
17 KB (1,619 words) - 12:55, 26 October 2024
14.14.153, indole-2-monooxygenase EC 1.14.13.138: Now EC 1.14.14.157, indolin-2-one monooxygenase EC 1.14.13.139: Now EC 1.14.14.109, 3-hydroxyindolin-2-one...
189 KB (24,607 words) - 12:36, 11 June 2024
Dallanoce C (April 17, 2014). "A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor...
44 KB (5,009 words) - 23:11, 18 October 2024
(February 2007). "SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial...
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reaction indole + NAD(P)H + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } indolin-2-one + NAD(P)+ + H2O Indole-2-monooxygenase is involved in the biosynthesis...
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Identifiers IUPAC name 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl]-2-(3-trifluoromethylphenyl)ethanone CAS Number 1337531-36-8 Y PubChem...
3 KB (284 words) - 11:57, 16 January 2024
Later, series of more selective c-Met inhibitors were designed, where an indolin-2-one core (encircled in figure 1) was present in several kinase inhibitors...
32 KB (3,542 words) - 19:34, 2 July 2024