Neprilysin (/ˌnɛprɪˈlaɪsɪn/; also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10) and...
23 KB (2,581 words) - 06:57, 21 July 2024
fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan. The...
37 KB (3,449 words) - 21:45, 1 August 2024
(LBQ657) by de-ethylation via esterases. Sacubitrilat inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic...
7 KB (526 words) - 15:48, 25 March 2024
at pH 2. Glutamyl endopeptidase - cuts after Glu. Works best at pH 8. Neprilysin "endopeptidase". Merriam-Webster. Archived from the original on 21 December...
2 KB (226 words) - 19:03, 18 December 2023
(ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969.: 120 The angioedema appears to be dose dependent as...
3 KB (287 words) - 05:50, 31 October 2023
nesiritide in patients with acute decompensated heart failure. Blockade of neprilysin, a protease known to degrade members of the natriuretic peptide family...
38 KB (4,329 words) - 02:33, 28 March 2024
different kininases: angiotensin-converting enzyme (ACE, kininase II), neprilysin, NEP2, aminopeptidase P (APP), carboxypeptidase N (CPN, kininase I), Carboxypeptidase...
20 KB (2,007 words) - 21:03, 25 June 2024
experimental antihypertensive agent that was never marketed. It inhibits both neprilysin (neutral endopeptidase, NEP) and angiotensin-converting enzyme (ACE)....
5 KB (231 words) - 23:42, 22 January 2023
Natriuretic peptides will lose their activity when degraded by the enzyme neprilysin which is found on the plasma membrane. The existence of natriuretic peptides...
15 KB (1,731 words) - 19:18, 3 April 2024
Petersburg, Russia, est. 1988 Nepal, FIFA and IOC code NEP Nepr, a Norse god Neprilysin, or neutral endopeptidase Needle exchange programme Net ecosystem production...
1 KB (175 words) - 02:30, 15 August 2024