Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine...

that certain SNPs in the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene can...

genetic factors that predispose disease onset including HLA-B27 and the PTPN22 genotype. Recent evidence has pointed to reactivation of herpes simplex...

of susceptibility to lupus erythematosus). In recent studies, the gene PTPN22 has emerged as a significant factor linked to various autoimmune diseases...

analysis. CTLA-4 was confirmed as the main locus for thyroid autoantibodies. PTPN22 is the most recently identified immune-regulatory gene associated with autoimmune...

protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype showed significant association with anti-topo I. The...

people with GPA. Several genes involved in the immune system including PTPN22, CTLA4, and human leukocyte antigen genes may influence the risk of developing...

CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22), and innate immune activation—appear to have less influence than HLA mutations...

phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations. GRCh38: Ensembl release...

increased risk of SLE. Other genes that contain risk variants for SLE are IRF5, PTPN22, STAT4, CDKN1A, ITGAM, BLK, OX40L and BANK1. Some of the susceptibility...