Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from...

pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. Therapeutically, fexofenadine is a selective peripheral H1 blocker...

or preventing gout inflammation. Colchicine appears to be a peripherally selective drug with limited brain uptake due to binding to P-glycoprotein. The...

14.5 h and plasma protein binding of 84–90%. Bilastine is a peripherally selective drug, and this thought to be due to limited brain uptake caused by...

highly selective serotonin 5-HT3 receptor antagonist, with low affinity for dopamine receptors. The 5-HT3 receptors are present both peripherally on vagal...

blood–brain barrier under normal circumstances and hence is a peripherally selective drug. Norepinephrine is the INN while noradrenaline is the BAN. Andersen...

chiral switch of (±)-cetirizine. This enantiomer, the eutomer, is more selective and the (S)-counterpart, the distomer, is inactive. Chemically, levocetirizine...

no reported cases of clinically evident drug-induced liver injury associated with bisoprolol. Non-selective beta-blockers should be avoided in people...

Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H1 receptors. The potency of second generation...

significantly cross the blood–brain barrier. As a result, it is a peripherally selective drug and does not act in the brain. Entacapone is primarily metabolized...