preclinical research, such as that on average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes...

New forms of male contraception are in clinical and preclinical stages of research and development, but as of 2024, none have reached regulatory approval...

The entire process—from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials—to approved...

personalized medicine. In 2019, a report was published detailing the development of milasen, an antisense oligonucleotide drug for Batten disease, under...

inhibitor (DRI) that was derived from modafinil. It was an early lead in the development of novel modafinil analogues with improved properties for potential use...

developmental code name GLYX-13) is a novel antidepressant that was under development by Allergan (previously Naurex) as an adjunctive therapy for the treatment...

nauseous. A number of in vitro and in vivo models lend themselves to preclinical evaluation of novel pulmonary therapies. In vitro, exposure of human...

Assay development → High-throughput screening (HTS) → Hit to lead (H2L) → Lead optimization (LO) → Preclinical development → Clinical development The hit...

to target brain areas where seizures arise, in order to prevent the development of epilepsy or to reduce the frequency and/or severity of seizures. Gene...

vaccine and develop the required antibodies.[citation needed] Preclinical development stages are necessary to determine the immunogenicity potential...