Prosaposin, also known as PSAP, is a protein which in humans is encoded by the PSAP gene. This highly conserved glycoprotein is a precursor for 4 cleavage...
14 KB (1,791 words) - 14:17, 9 October 2024
All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after...
6 KB (657 words) - 08:25, 11 December 2023
cases, it may be caused by a lack of active saposin A (a derivative of prosaposin). The buildup of unmetabolized lipids adversely affects the growth of...
23 KB (2,390 words) - 19:54, 23 August 2024
infantile Tay–Sachs Metachromatic leukodystrophy (MLD) Arylsulfatase A or prosaposin Sulfatide compounds in neural tissue Demyelination in CNS and PNS: Mental...
10 KB (652 words) - 23:45, 13 August 2024
angiogenesis. Moreover, stimulating TSP1 via over-expressing prosaposin or treating with a small prosaposin-derived peptide potently inhibits and even induces regression...
19 KB (2,345 words) - 04:52, 3 June 2024
LAMP2, GNS/N-acetylglucosamine-6-sulfatase, TSPAN6/tetraspanin-6, PSAP/prosaposin, and TMEM192/transmembrane protein 192 may contribute to the execution...
119 KB (12,658 words) - 19:25, 19 September 2024
Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: Prosaposin-like 1 (gene/pseudogene)". Retrieved 2013-04-11. v t e...
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protein Protein phosphatase with ef-hand domain 2 PSAPL1: encoding protein Prosaposin-like 1 (gene/pseudogene) QDPR: quinoid dihydropteridine reductase RBM47:...
31 KB (1,931 words) - 03:29, 25 August 2024
lysosome. One recent study has shown that progranulin may actually mediate prosaposin trafficking to the lysosome via SORT1. However, the absence of SORT1 does...
32 KB (3,334 words) - 03:20, 29 November 2023
glycosylation sites. The cDNA sequence that codes for saposin is called prosaposin. It is a precursor for four cleavage products, the saposins A, B, C, and...
35 KB (3,511 words) - 04:34, 24 May 2024