Rofecoxib is a COX-2-selective nonsteroidal anti-inflammatory drug (NSAID). It was marketed by Merck & Co. to treat osteoarthritis, rheumatoid arthritis...
76 KB (8,141 words) - 20:25, 3 August 2024
reduces the risk of peptic ulceration and is the main feature of celecoxib, rofecoxib, and other members of this drug class. After several COX-2–inhibiting...
42 KB (4,944 words) - 11:56, 4 April 2024
complicated upper gastrointestinal events are similar between two groups. Like rofecoxib's VIGOR trial, the MEDAL Program was also criticized, this time due to...
13 KB (1,155 words) - 10:55, 15 July 2024
became the building-block for synthesis of COX-2 inhibitors. Celecoxib and rofecoxib, the first COX-2 inhibitors to reach market, were based on DuP-697. It...
37 KB (4,463 words) - 13:48, 4 June 2023
heart attack. As a result, certain COX-2 selective inhibitors—such as rofecoxib—are no longer used due to the high risk of undiagnosed vascular disease...
110 KB (11,559 words) - 22:46, 13 August 2024
(traditional NSAIDs block both versions in general). These drugs (such as rofecoxib, celecoxib, and etoricoxib) are equally effective analgesics when compared...
109 KB (5,854 words) - 03:07, 24 August 2024
advice to physicians regarding celecoxib's safety. The COX-2 inhibitor rofecoxib (Vioxx) was removed from the market in 2004 due to its risk. Like all...
61 KB (6,082 words) - 05:23, 17 June 2024
the dosage and its effects are comparable to human medications such as rofecoxib and piroxicam. Grapiprant has also been tested in humans, and was researched to...
11 KB (1,033 words) - 23:56, 28 March 2024
double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee". Drugs. 63 (Suppl 1): 37–46. doi:10...
18 KB (1,753 words) - 20:40, 17 July 2024
COX-2 inhibitors Celecoxib (+tramadol) Etoricoxib Lumiracoxib ‡ Parecoxib Rofecoxib ‡ Valdecoxib ‡ Fenamates Flufenamic acid Meclofenamic acid Mefenamic acid...
118 KB (11,360 words) - 22:58, 23 August 2024