is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins...
119 KB (12,654 words) - 00:05, 31 July 2024
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function...
57 KB (6,278 words) - 21:51, 24 August 2024
MTORC1 (redirect from MTOR Complex 1)
controls protein synthesis. mTOR Complex 1 (mTORC1) is composed of the mTOR protein complex, regulatory-associated protein of mTOR (commonly known as raptor)...
69 KB (7,803 words) - 11:01, 11 April 2024
MTORC2 (redirect from MTOR Complex 2)
mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and...
34 KB (3,795 words) - 00:38, 8 July 2024
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence...
36 KB (4,322 words) - 11:55, 11 August 2024
rejection of kidney transplants. It is a mechanistic target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to...
69 KB (6,838 words) - 09:56, 30 July 2024
of cell signaling and cancer metabolism, most notably the co-discovery of mTOR. In 2021 and 2022, Sabatini was fired from the Howard Hughes Medical Institute...
21 KB (2,070 words) - 03:38, 18 June 2024
the NMDA receptor and downstream effects on regulators such as BDNF and mTOR. It is not clear whether ketamine alone is sufficient for antidepressant...
117 KB (11,360 words) - 18:24, 12 September 2024
the mTOR pathway also plays a role in beta cell growth leading to insulin secretion. High glucose in the blood begins the process of the mTOR signaling...
29 KB (3,420 words) - 20:54, 29 August 2024
genes under investigation in ASD pathophysiology are those that affect the mTOR signaling pathway, which supports cell growth and survival. All these genetic...
255 KB (27,008 words) - 01:44, 14 September 2024