DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms...
57 KB (6,173 words) - 00:11, 11 December 2023
Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases...
85 KB (9,593 words) - 14:56, 17 October 2024
Topoisomerase IV is one of two Type II topoisomerases in bacteria, the other being DNA gyrase. Like gyrase, topoisomerase IV is able to pass one double-strand...
3 KB (375 words) - 21:08, 29 March 2021
In molecular biology Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand...
19 KB (2,345 words) - 07:02, 26 August 2024
Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use...
31 KB (3,943 words) - 21:17, 12 September 2024
Anti-Scl-70 antibodies (redirect from Anti-topoisomerase I)
Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies...
2 KB (226 words) - 18:42, 28 June 2022
TOP2B (redirect from Topoisomerase II beta)
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters...
19 KB (2,287 words) - 10:45, 3 September 2024
TOP1 (redirect from Topoisomerase I)
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking...
16 KB (2,141 words) - 02:28, 29 November 2023
TOP3A (redirect from Topoisomerase III alpha)
DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene. This gene encodes a DNA topoisomerase, an enzyme that controls and...
13 KB (1,648 words) - 23:57, 17 August 2023
Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases...
9 KB (870 words) - 07:54, 22 August 2024