c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional...
14 KB (1,626 words) - 20:50, 30 May 2024
apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase. Cytotrienin A is...
8 KB (736 words) - 21:15, 30 September 2024
mammalian MAPK family of kinases includes three subfamilies: Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated...
46 KB (5,492 words) - 05:56, 16 October 2024
the c-jun target genes. Therefore, regulation of c-jun activity can be achieved through N-terminal phosphorylation by the Jun N-terminal kinases (JNKs)...
45 KB (5,452 words) - 05:07, 13 July 2024
neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in...
11 KB (1,348 words) - 06:45, 11 March 2024
include the extracellular regulated kinases (ERKs), the c-Jun N-terminal Kinases (JNKs), and the p38 MAP kinase. The ERKs are regulated by the Raf family...
11 KB (1,345 words) - 09:11, 2 January 2024
(SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes...
7 KB (626 words) - 07:37, 1 April 2024
protein kinases (MAPK). These include extracellular signal-regulated kinase, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases. The synthetic...
68 KB (7,816 words) - 22:20, 21 September 2024
RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains...
5 KB (556 words) - 08:06, 3 June 2024
follows: IAA/HRP activates p38 mitogen-activated protein kinases and c-Jun N-terminal kinases. It induces caspase-8 and caspase-9, which results in caspase-3...
26 KB (2,766 words) - 04:33, 4 October 2024