• Thumbnail for Integrin alpha L
    Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans...
    10 KB (1,239 words) - 08:31, 10 June 2024
  • Thumbnail for ICAM-1
    endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor...
    19 KB (2,409 words) - 16:20, 11 December 2023
  • Thumbnail for Von Willebrand factor type A domain
    determined for the I-domains of integrins CD11b (with bound magnesium) and CD11a (with bound manganese). The domain adopts a classic alpha/beta Rossmann...
    8 KB (791 words) - 11:13, 28 March 2024
  • component is CD18 (β2) and mediate leukocyte adhesion. For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1,...
    1,012 bytes (87 words) - 01:41, 12 July 2023
  • administered once weekly by subcutaneous injection. Efalizumab binds to the CD11a subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant...
    7 KB (367 words) - 19:53, 20 December 2023
  • Thumbnail for Neutrophil
    located on the αM chain (CD11b) and HNA-5 is located on the αL integrin unit (CD11a). Two functionally unequal subpopulations of neutrophils were identified...
    54 KB (5,770 words) - 22:58, 3 November 2024
  • Thumbnail for Follicular dendritic cells
    Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)–LFA-1 (CD11a) and VCAM–VLA-4 molecules. Activated B-cells with low affinity to antigen...
    16 KB (1,896 words) - 15:59, 6 April 2024
  • Otelixizumab Teplizumab Visilizumab CD4 Clenoliximab Keliximab Zanolimumab CD11a Efalizumab CD18 Erlizumab CD20 Obinutuzumab Ocrelizumab (+hyaluronidase)...
    7 KB (299 words) - 13:45, 27 April 2024
  • Thumbnail for Integrin beta 2
    integrins. The known binding partners of CD18 are CD11a, CD11b, CD11c and CD11d. Binding of CD18 and CD11a results in the formation of lymphocyte function-associated...
    11 KB (1,299 words) - 10:15, 11 December 2023
  • Thumbnail for Psoriasis
    alefacept. Efalizumab is a monoclonal antibody that specifically targets the CD11a subunit of LFA-1. It also blocks the adhesion molecules on the endothelial...
    116 KB (13,061 words) - 15:20, 6 November 2024