CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues...
11 KB (1,377 words) - 05:00, 15 December 2023
(LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1. A link between high cholesterol and breast cancer has been identified...
3 KB (244 words) - 04:27, 19 December 2023
sterol 27-hydroxylase (CYP27A1), but vitamin D2 cannot. Ergocalciferol can be directly hydroxylated at position 24 by CYP27A1. This hydroxylation also...
163 KB (17,848 words) - 04:39, 12 September 2024
mitochondrial sterol 27-hydroxylase (CYP27A1), expressed in liver, and also in macrophages and other tissues. CYP27A1 contributes significantly to total...
36 KB (4,587 words) - 11:51, 6 September 2024
receptor. Unlike cholecalciferol, 25-hydroxylation is not performed by CYP27A1 for ergocalciferol. Ergocalciferol and metabolites have lower affinity...
24 KB (2,002 words) - 03:34, 2 September 2024
acid metabolism disorder caused by autosomal-recessive mutations in the CYP27A1 gene. CTX is characterized by a wide range of symptoms, including neurological...
24 KB (2,267 words) - 02:19, 4 September 2024
CYP2R1, present in microsomes, although other enzymes such as mitochondrial CYP27A1 can contribute. Variations in the expression and activity of CYP2R1, such...
20 KB (1,953 words) - 16:13, 26 April 2024
Cerebrotendinous xanthomatosis Medical genetics, endocrinology Autosomal recessive CYP27A1 1/70 Morocco Cystinuria Endocrinology Autosomal recessive SLC7A9 1/25 Libya...
46 KB (4,083 words) - 15:18, 6 September 2024
(steroid 21-hydroxylase) CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase) CYP27A1 (sterol 27-hydroxylase) CYP27B1 (25-hydroxyvitamin D3 1α-hydroxylase) CYP39A1...
9 KB (78 words) - 09:09, 12 November 2023
active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3). The...
41 KB (4,157 words) - 16:35, 28 August 2024