Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine...

inhibitory phosphates on CDK1 and thus convert the cyclin B1-CDK1 complex to its fully activated form, MPF. Active cyclinB1-CDK1 phosphorylates and modulates...

via cyclin B-Cdk1 phosphorylation. As these previous checkpoints are assessed, G2 protein accumulation serves to activate cyclin B-Cdk1 activity via multiple...

and S phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive...

29 cyclins illustrates their complex regulatory roles. Key CDKs such as CDK1 are indispensable for cell cycle control, while others like CDK2 and CDK3...

at the time of discovery. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage...

Clb6 bind and activate Cdk1, and high levels of these cyclins are required for entering S-phase. S-phase cyclin binding to Cdk1 directly stimulates DNA...

locations. Cyclins, when bound with the dependent kinases, such as the p34/cdc2/cdk1 protein, form the maturation-promoting factor. MPFs activate other proteins...

Ultrasensitivity plays a large role in cell-cycle regulation. For example, Cdk1 and Wee1 are mitotic regulators, and they are able to inactivate each other...

family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle...